Manipulating the kinetics and site of colonic fermentation with different fibre combinations – a review

The effects of dietary fibre on gut microbiota and the colonic markers health have been well investigated, along with kinetics fermentation. Most evidence available is based faecal analysis or static in vitro models fermentation constant amounts fibres incubated individually inoculum. These results offer a limited understanding different bacterial species, changes that occur GI tract, when patterns involving mixed sources consumed single day are considered. normal transit time 40–60 h. With three meals day, undigested nutrients tend to accumulate colon as they traverse from proximal distal colon. There an evolving need for paradigm shift nutritional research investigate metabolomic physiological combination, pattern daily meals. We propose framework harness health-beneficial metabolites by manipulating site resulting interplay between rates Based this framework, hypothesis developed reduce side effect excessive gas production indigestible oligosaccharides legumes such chickpeas soybean.